Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model

作者: Dae Jin Song , Jae Youn Cho , Marina Miller , Wendy Strangman , Mai Zhang

DOI: 10.1016/J.CLIM.2008.11.009

关键词:

摘要: Siglec-F is a sialic acid binding immunoglobulin-superfamily receptor that highly expressed on eosinophils. We have used mouse model of oral egg ovalbumin (OVA)-induced eosinophilic inflammation the gastro-intestinal mucosa associated with diarrhea and weight loss to determine whether administering an anti-Siglec-F antibody would reduce levels intestinal mucosal inflammation. Mice administered had significantly lower inflammation, this was reduced permeability changes, normalization villous crypt height, restoration gain. The numbers eosinophils in treated mice bone marrow peripheral blood eosinophils, but not significant changes proliferating or apoptotic jejunal In addition, Ab Th2 cytokines IgE levels. Overall, these studies demonstrate administration reduces

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