Emerging drugs for the treatment of gastroparesis

摘要: Introduction: Gastroparesis presents with symptoms of gastric retention findings delayed emptying on diagnostic testing. Manifestations gastroparesis are disabling in severe cases and lead to significant health resource utilization. Current therapies often ineffective, may exhibit tolerance chronic administration or produce prominent side effects large patient subsets. Areas covered: This review assessed literature drugs theoretical efficacy including medications that accelerate emptying, reduce nausea vomiting, act as neuromodulators sensitivity. Numerous agents diverse actions modify sensorimotor function animal models; however, few controlled testing gastroparesis. Prokinetic promise for this condition include investigational serotonin 5-HT4 agonists, motilin dopamine D2 antagonists, ghrelin agonists an agent combined muscarinic antagonist ...