Dosimetric impact of respiratory motion, interfraction baseline shifts, and anatomical changes in radiotherapy of non-small cell lung cancer
作者： Mai Lykkegaard Schmidt , Lone Hoffmann , Maria Kandi , Ditte S. Møller , Per Rugaard Poulsen
DOI: 10.3109/0284186X.2013.815798
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摘要: AbstractBackground. The survival rates for patients with non-small cell lung cancer (NSCLC) may be improved by dose escalation; however, margin reduction required in order to keep the toxicity at an acceptable level. In this study we have investigated dosimetric impact of tumor motion and anatomical changes during intensity-modulated radiotherapy (IMRT) NSCLC. Material methods. Sixteen NSCLC received IMRT concomitant chemotherapy. lymph node targets were delineated mid-ventilation phase a planning 4DCT scan (CT1). Typically 66 Gy was delivered 33 fractions using daily CBCT bony anatomy match patient setup. baseline shifts mean position relative spine extracted from scans. A second (CT2) acquired halfway through treatment course respiratory extracted. plan recalculated on CT2 without inclusion motio...
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