Antigenicity of the β-Chain of Human Hæmoglobin

摘要: HUMAN haemoglobin is a weak antigen1–4 but potentially antigenic sites may be concealed in the interior of folded molecule. In contrast, isolated polypeptide chains have little conformational rigidity, and these, therefore, more accessible. Accordingly, we investigated properties separate α- β-chains human globin used two immunological assay systems that allow an examination specificity.