The action of vasodilating drugs on isolated basilar, coronary and mesenteric arteries of the dog.

摘要: Effects of vasodilating drugs were compared in helical strips canine basilar, coronary and mesenteric arteries contracted with K + . Papaverine caused a dose-dependent relaxation, the maximum relaxation being attained at 10 -4 M these three arteries. Adenosine NaNO 2 , also produced difference dose-response relationships was only slight. Similar response to adenosine observed human basilar Relaxation induced by isoproterenol appreciably greater arterial than mesentenic dogs humans slight even high concentrations. Acetylcholine elicited dose-realted which inhibited treatment atropine but not propranolol. In arteries, produced. strips, acetylcholine biphasic responses, low concentrations contraction The reversed phenoxybenzamine. release catecholamines may be involved genesis acetylcholine-induced contraction. It appears that as far are concerned, adrenergic cholinergic vasodilator mechanisms do play major role regulation vascular tone.