Glutamine Structure and Function: A Starter Pack

摘要: Glutamine is a substrate central in metabolism. Its carbon skeleton can act as an anaplerotic by introduction α-oxoglutarate the Krebs-cycle. At other sites of cycle intermediates branch off producing chains purines, pyrimidines, haem, proline, aspartate, non-essential amino acids, sterols, phospholipids. nitrogen serves similar manner to synthesize bases, groups acids and products. A third role consists production reducing equivalents essential several functions including maintenance redox balance. This explains why cell culture optimal proliferation only occurs when glutamine (and glucose) are added incubation medium.