Electrolytic transdermal delivery of polypeptides

摘要: The invention comprises in combination: (a) a polypeptide having from about three to 20 peptide units aqueous solution or suspension, and (b) an electrolytic device for transdermal transport of the bloodstream patient. It may be useful enhance delivery by adding cosolute/cosolvent with negative Setschenow constants. preferably hydrophilic reservoir containing supply electric battery, two extended contacts, optionally semipermeable membrane between patient's skin. Representative polypeptides include oxytocin, angiotensin I, II, III, substance P, vasopressin, lypressin, desmopressin, leuprolide acetate, antripeptin, like.