Cell proliferation and its relationship to clinical features and relapse in breast cancers

作者: Carla Gentili , Ornella Sanfilippo , Rosella Silvestrini

DOI: 10.1002/1097-0142(19810815)48:4<974::AID-CNCR2820480420>3.0.CO;2-#

关键词:

摘要: The relationship between primary tumor proliferative activity and clinical pathologic characteristics was analyzed in relation to menopausal status for 541 breast cancer patients. thymidine-3H labeling index (LI) showed significantly higher median values cancers from premenopausal (4.2%) paramenopausal patients comparison that of postmenopausal (1.8%) LI not generally correlated size. only significant correlation limited tumors with negative axillary lymph nodes neither the presence nor extension metastasis. prognostic significance assessed 145 untreated without metastases. A value observed who relapsed (5.7%) within 52 months than those did relapse (2%). However, difference statistically (P less 0.01) patients, but Similarly, a 0.0005) rate (67.4%) had above 4.6% (0%) below No risk

参考文章(18)
George Crile, Breast cancer The American Journal of Surgery. ,vol. 124, pp. 35- 38 ,(1972) , 10.1016/0002-9610(72)90161-4
Jacqueline S. Hart, Stephen L. George, Robert B. Livingston, Emil J Freireich, Ulo Ambus, In Vitro Determination of Thymidine-3H Labeling Index in Human Solid Tumors Cancer Research. ,vol. 34, pp. 1376- 1380 ,(1974)
Jose J. Terz, H. Pablo Curutchet, Walter Lawrence, Analysis of the cell kinetics of human solid tumors. Cancer. ,vol. 28, pp. 1100- 1110 ,(1971) , 10.1002/1097-0142(1971)28:5<1100::AID-CNCR2820280503>3.0.CO;2-1
John S. Meyer, Walter C. Bauer, Tritiated thymidine labeling index of benign and malignant human breast epithelium. Journal of Surgical Oncology. ,vol. 8, pp. 165- 181 ,(1976) , 10.1002/JSO.2930080212
L. M. Schiffer, P. G. Braunschweiger, J. J. Stragand, L. Poulakos, The cell kinetics of human mammary cancers Cancer. ,vol. 43, pp. 1707- 1719 ,(1979) , 10.1002/1097-0142(197905)43:5<1707::AID-CNCR2820430522>3.0.CO;2-A
Rosella Silvestrini, Maria Grazia Daidone, Giovanni Di Fronzo, Relationship between proliferative activity and estrogen receptors in breast cancer Cancer. ,vol. 44, pp. 665- 670 ,(1979) , 10.1002/1097-0142(197908)44:2<665::AID-CNCR2820440237>3.0.CO;2-N
Bernard Fisher, Andrew Glass, Carol Redmond, Edwin R Fisher, Bruce Barton, Emillie Such, Paul Carbone, Steven Economou, Roger Foster, Robert Frelick, Harvey Lerner, Martin Levitt, Richard Margolese, John MacFarlane, David Plotkin, Henry Shibata, Herbert Volk, None, L-phenylalanine mustard (L-PAM) in the management of primary breast cancer:An update of earlier findings and a comparison with those utilizing L-PAM plus 5-fluorouracil (5-FU) Cancer. ,vol. 39, pp. 2883- 2903 ,(1977) , 10.1002/1097-0142(197706)39:6<2883::AID-CNCR2820390676>3.0.CO;2-9