Characterization of antimicrobial-resistant Escherichia coli causing urinary tract infections in dogs: Passive surveillance in Saskatchewan, Canada 2014 to 2018.
作者： Joseph E. Rubin , Michelle Sniatynski , Rachel Courtice
DOI: 10.1111/JVIM.16103
关键词:
摘要: BACKGROUND Urinary tract infections (UTIs) are common in dogs and can be caused by multidrug-resistant Escherichia coli (E coli). OBJECTIVE To describe the frequency mechanisms of antimicrobial resistance (AMR) among E causing UTIs Western Canada during a 4-year surveillance period. ANIMALS Urine from 516 dogs. METHODS From November 2014 to 2018, nonduplicate isolates urine were collected diagnostic laboratory. Susceptibility testing was determined for panel 14 antimicrobials belonging 7 drug classes. Resistant screened presence extended-spectrum beta-lactamases (ESBLs), AmpC β-lactamases, plasmid-mediated quinolone (PMQR) genes. Epidemiological relationships assessed MLST. RESULTS 80.2% (414/516) susceptible all tested. There no significant increase proportion resistant any tested study Resistance ampicillin most (14.9%, 77/516). Overall, 12 had blaCMY-2 -type produced CTX-M-type ESBLs. A single isolate aac(6')-Ib-cr PMQR gene. The qnr qepA determinants not detected. pandemic lineage ST131 identified. CONCLUSION isolated our region remain first-line therapies, though resistance, particularly aminopenicillins, warrants monitoring. This is first description companion animal Canada.
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