Complement regulation: physiology and disease relevance

摘要: The complement system is part of the innate immune response and as such defends against invading pathogens, removes complexes damaged self-cells, aids organ regeneration, confers neuroprotection, engages with adaptive via T B cells. Complement activation can either benefit or harm host organism; thus, must maintain a balance between on foreign modified self surfaces inhibition intact regulators are essential for maintaining this classified soluble regulators, factor H, membrane-bound regulators. Defective damage cell result in accumulation immunological debris. Moreover, defective associated several autoimmune diseases atypical hemolytic uremic syndrome, dense deposit disease, age-related macular degeneration, systemic lupus erythematosus. Therefore, understanding molecular mechanisms by which regulated important development novel therapies complement-associated diseases.