Hyperemesis gravidarum and risk of cancer in offspring, a Scandinavian registry-based nested case–control study

摘要: Background: Hyperemesis gravidarum is a serious condition affecting 0.8–2.3 % of pregnant women and can be regarded as restricted period famine. Research concerning potential long-term consequences the for offspring, limited, but lack nutrition in-utero has been associated with chronic disease in adulthood, including some cancers. There growing evidence that several forms cancer may originate during fetal life. We conducted large study linking high-quality population-based medical birth- registries Norway, Sweden Denmark, to explore whether hyperemesis increased risk offspring. Methods: A registry-based nested case–control study. Twelve types childhood were selected; leukemia, lymphoma, central nervous system, testis, bone, ovary, breast, adrenal thyroid gland, nephroblastoma, hepatoblastoma retinoblastoma. Conditional logistic regression models applied associations between cancer, both all combined separately. Cancer five or more exposed cases stratified by age at diagnosis. All analysis adjusted maternal age, ethnicity smoking, addition offspring’s Apgar score, placental weight birth weight. Relative risks 95 confidence intervals calculated. Results: In total 14,805 approximately ten controls matched on time, country birth, sex year per case (147,709) identified. None types, analyzed separately, revealed significant association hyperemesis. When according diagnosis, we observed RR 2.13 lymphoma among adolescents aged 11–20 years ((95 CI 1.14–3.99), after adjustment 2.08 (95 1.11–3.90)). The finding was not apparent when stricter level statistical significance applied. Conclusions: main this paper does seem increase positive chance needs confirmation.