Systemic lanthanum is excreted in the bile of rats

摘要: Abstract Lanthanum carbonate is a non-calcium-based oral phosphate binder for the control of hyperphosphataemia in patients with chronic kidney disease Stage 5. As part its pre-clinical safety evaluation, studies were conducted rats to determine extent absorption and routes excretion. Following gavage single 1500 mg/kg dose, peak plasma lanthanum concentration was 1.04 ± 0.31 ng/mL, 8 h post-dose. almost completely bound proteins (>99.7%). Within 24 h administration 97.8 ± 2.84% recovered faeces rats. Comparing exposure after intravenous yielded an absolute bioavailability 0.0007%. chloride (0.3 mg/kg), 74.1 ± 5.82% dose (96.9 ± 0.50% lanthanum) excreted 42 days, bile-duct cannulated rats, 10.0 ± 2.46% (85.6 ± 2.97% bile 5 days. Renal excretion negligible,