Heart failure with preserved ejection fraction: from mechanisms to therapies

摘要: This review aims to provide a translational perspective on recent developments in heart failure with preserved ejection fraction (HFpEF), linking mechanistic insights potential therapies. A key concept this is that HFpEF haemodynamic condition wherein the fails keep up circulatory demands of body, or does so at expense raised left ventricular filling pressures. We, therefore, propose 'final common pathway' for development congestion, i.e. basic mechanisms increased end-diastolic pressure, atrial hypertension, pulmonary venous and plasma volume expansion, represents important initial targets therapy HFpEF. Accordingly, we group into six translating therapies HFpEF: beginning three (left expansion), working backward molecular [systemic microvascular inflammation, cardiometabolic functional abnormalities, cellular (titin)/extracellular (fibrosis) structural abnormalities].