Expression and localization of serotonin receptors in human breast cancer.
作者： Nishtman Dizeyi , Pradeep Kumar Kopparapu , Jenny Liao Persson , Martina Tinzl , Lola Anagnostaki
DOI:
关键词:
摘要: The aim of this study was to examine the expression serotonin receptors in patients with breast cancer and explore their utility as diagnostic prognostic markers. Immunohistochemical analysis performed (5-HT) receptor subtypes 1A, 1B, 2B 4 a tissue microarray containing tumor specimens from 102 patients. Statistical correlate these proteins regard clinical parameters. We found that all four (5-HTRs) exhibited different patterns specimens. In general strong staining for 5-HTR1A observed on membrane cells but it detected only cytoplasm non-malignant cells. 5-HTR1B 5-HTR2B were predominantly expressed cells, while 5-HTR4 exclusively nucleus malignant Correlation revealed significant correlation estrogen receptor-α (ER-α) ER-α progesterone (PR). conclusion, subcellular localization 5-HTRs may reflect role progression.
参考文章(34)
Matthew T. Drake, Sudha K. Shenoy, Robert J. Lefkowitz, Trafficking of G Protein–Coupled Receptors Circulation Research. ,vol. 99, pp. 570- 582 ,(2006) , 10.1161/01.RES.0000242563.47507.CE
T. Oufkir, C. Vaillancourt, Phosphorylation of JAK2 by serotonin 5-HT2A receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental choriocarcinoma cell Placenta. ,vol. 32, pp. 1033- 1040 ,(2011) , 10.1016/J.PLACENTA.2011.09.005
Leszek A Rybaczyk, Meredith J Bashaw, Dorothy R Pathak, Scott M Moody, Roger M Gilders, Donald L Holzschu, An overlooked connection: serotonergic mediation of estrogen-related physiology and pathology BMC Women's Health. ,vol. 5, pp. 12- 12 ,(2005) , 10.1186/1472-6874-5-12
Stephanie Geisler, Per Eystein Lønning, Turid Aas, Hilde Johnsen, Øystein Fluge, Dagny Faksvåg Haugen, Johan Richard Lillehaug, Lars Andreas Akslen, Anne-Lise Børresen-Dale, None, Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer. Cancer Research. ,vol. 61, pp. 2505- 2512 ,(2001)
Inês Domingues, José Rino, Jeroen A. A. Demmers, Primal de Lanerolle, Susana Constantino Rosa Santos, VEGFR2 Translocates to the Nucleus to Regulate Its Own Transcription PLoS ONE. ,vol. 6, pp. e25668- ,(2011) , 10.1371/JOURNAL.PONE.0025668
Christopher Soll, Marc-Oliver Riener, Christian Eugen Oberkofler, Claus Hellerbrand, Peter J. Wild, Michelle L. DeOliveira, Pierre-Alain Clavien, Expression of Serotonin Receptors in Human Hepatocellular Cancer Clinical Cancer Research. ,vol. 18, pp. 5902- 5910 ,(2012) , 10.1158/1078-0432.CCR-11-1813
D. Hoyer, David E Clarke, John R Fozard, PAUL R Hartig, Graeme R Martin, Ewan J Mylecharane, Pramod R Saxena, PP Humphrey, None, International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacological Reviews. ,vol. 46, pp. 157- 203 ,(1994)
Jeffrey M. Albert, Ana M. Gonzalez-Angulo, Merih Guray, Aysegul Sahin, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Susan L. Tucker, Kelly K. Hunt, Gabriel N. Hortobagyi, Thomas A. Buchholz, Estrogen/progesterone receptor negativity and HER2 positivity predict locoregional recurrence in patients with T1a,bN0 breast cancer. International Journal of Radiation Oncology Biology Physics. ,vol. 77, pp. 1296- 1302 ,(2009) , 10.1016/J.IJROBP.2009.12.011
V. Contesse, Y. Reznik, C. Duparc, V. Perraudin, H. Vaudry, J. M. Kuhn, H. Lefebvre, Effects of serotonin and vasopressin on cortisol production from an adrenocortical tumor causing subclinical Cushing's syndrome. Endocrine Research. ,vol. 28, pp. 787- 791 ,(2002) , 10.1081/ERC-120017074
Stephen S. G. Ferguson, Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling Pharmacological Reviews. ,vol. 53, pp. 1- 24 ,(2001)