Cyclooxygenase-2 Expression in Helicobacter pylori-Associated Premalignant and Malignant Gastric Lesions

摘要: Expression of cyclooxygenase-2 (COX-2) in various stages the Helicobacter pylori-associated gastric carcinogenesis pathway has not been elucidated. We investigated distribution and intensity COX-2 expression premalignant malignant lesions, monitored changes after H. pylori eradication. Gastric biopsies from pylori-infected patients with chronic active gastritis, atrophy, intestinal metaplasia (IM), adenocarcinoma, noninfected controls were studied. was evaluated by immunohistochemistry situ hybridization. Endoscopic repeated 1 year successful eradication a group IM for comparing progression IM. In all patients, predominantly found foveolar glandular epithelium and, to lesser extent, lamina propria. group, only 35% cases demonstrated weak expression. Intensity significantly different between IM, adenocarcinoma groups. 17 expressions epithelial cells stromal reduced However, did correlate progression/regression Both lesions demonstrate strong Successful leads down-regulation but failed reverse at year.