Antioxidant therapy for idiopathic pulmonary fibrosis. A promising therapeutic prospect

Q Ye, J Guzman, S Nakamura, R Sarria, U Costabel, A Cu, N-acetylcysteine inhibits TNF-alpha, sTNFR, and TGF-beta1 release by alveolar macrophages in idiopathic pulmonary fibrosis in vitro. Sarcoidosis Vasculitis and Diffuse Lung Diseases. ,vol. 26, pp. 147- 154 ,(2009)

A. Gillissen, D. Nowak, Characterization of N-acetylcysteine and ambroxol in anti-oxidant therapy Respiratory Medicine. ,vol. 92, pp. 609- 623 ,(1998) , 10.1016/S0954-6111(98)90506-6

André M. Cantin, Pierre Larivée, Raymond O. Begin, Extracellular glutathione suppresses human lung fibroblast proliferation. American Journal of Respiratory Cell and Molecular Biology. ,vol. 3, pp. 79- 85 ,(1990) , 10.1165/AJRCMB/3.1.79

T. J. Broekelmann, A. H. Limper, T. V. Colby, J. A. McDonald, Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 6642- 6646 ,(1991) , 10.1073/PNAS.88.15.6642

Moisés Selman, Talmadge E. King, Annie Pardo, Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Annals of Internal Medicine. ,vol. 134, pp. 136- 151 ,(2001) , 10.7326/0003-4819-134-2-200101160-00015

Hiromi TOMIOKA, Youichirou KUWATA, Kazufumi IMANAKA, Kimio HASHIMOTO, Hisashi OHNISHI, Kimihide TADA, Hiroko SAKAMOTO, Hironobu IWASAKI, A pilot study of aerosolized N‐acetylcysteine for idiopathic pulmonary fibrosis Respirology. ,vol. 10, pp. 449- 455 ,(2005) , 10.1111/J.1440-1843.2005.00725.X

SHIN-ICHI HAGIWARA, YOSHIKI ISHII, SATOSHI KITAMURA, Aerosolized Administration of N-Acetylcysteine Attenuates Lung Fibrosis Induced by Bleomycin in Mice American Journal of Respiratory and Critical Care Medicine. ,vol. 162, pp. 225- 231 ,(2000) , 10.1164/AJRCCM.162.1.9903129

André M. Cantin, Richard C. Hubbard, Ronald G. Crystal, Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract in idiopathic pulmonary fibrosis. The American review of respiratory disease. ,vol. 139, pp. 370- 372 ,(1989) , 10.1164/AJRCCM/139.2.370

TM Maher, AU Wells, GJ Laurent, None, Idiopathic pulmonary fibrosis: multiple causes and multiple mechanisms? European Respiratory Journal. ,vol. 30, pp. 835- 839 ,(2007) , 10.1183/09031936.00069307

RJ McAnulty, B Sarnstrand, PK Jeffery, GJ Laurent, S Shahzeidi, Oral N-acetylcysteine reduces bleomycin-induced collagen deposition in the lungs of mice. European Respiratory Journal. ,vol. 4, pp. 845- 852 ,(1991)