Reactive Oxygen species and cerebrovascular diseases

摘要: In the normal physiologic state, reactive oxygen species (ROS) generation is intentional and important for functioning of cerebral systemic circulations. Furthermore, emerging evidence indicates that arteries generate higher levels ROS than outside brain in state. As such, it has been proposed may play a more prominent role regulation arteries. There are numerous potential enzymatic sources vasculature; however, increasing family NADPH oxidases major source. Aberrant redox signaling or oxidative stress circulation, usually as result excessive production nitrogen (RNS), common feature diverse models cardiovascular risk factors (e.g., hypertension, hypercholesterolemia) cerebrovascular disease. now believed to be an underlying cause dysfunction damage associated with these disease states. this chapter, we summarize effects roles ROS/RNS modulating artery function particular focus on their tone. will highlight current involvement factors, stroke, Alzheimer's