Solid and Suspension Microarrays for Microbial Diagnostics

作者: Steve Miller , Ulas Karaoz , Eoin Brodie , Sherry Dunbar

DOI: 10.1016/BS.MIM.2015.04.002

关键词:

摘要: Abstract Advancements in molecular technologies have provided new platforms that are being increasingly adopted for use the clinical microbiology laboratory. Among these, microarray methods particularly well suited diagnostics as they allow multiplexing, or ability to test multiple targets simultaneously from same specimen. Microarray commonly used detection and identification of microbial include solid-state microarrays, electronic microarrays bead suspension microarrays. been applied detection, genotyping antimicrobial resistance gene detection. Microarrays can offer a panel approach diagnose specific patient presentations, such respiratory gastrointestinal infections, discriminate isolates by genotype tracking epidemiology outbreak investigations. And, more information has become available on genes pathways involved resistance, we beginning be able predict susceptibility patterns based sequence particular organisms. With further advances automated processing genotype–phenotype prediction algorithms, these tests will even useful an adjunct replacement conventional testing, allowing rapid selection targeted therapy infectious diseases.

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