Prognostic significance of tumor infiltrating immune cells in oral squamous cell carcinoma

摘要: Prognostic factors aid in the stratification and treatment of cancer. This study evaluated prognostic importance tumor infiltrating immune cell patients with oral squamous carcinoma. Profiles cells clinicopathological data were available for 78 OSCC a median follow-up 48 months. The intensity CD8, CD4, T-bet, CD68 CD57 positive assessed by immunohistochemistry. Chi-square test was used to compare markers expression parameters. Univariate multivariate COX proportional hazard models assess discriminator power cells. predictive potential survival determined using ROC AUC. mean value 28.99, 62.06, 8.97, 21.25 15.75 per high-power field respectively. patient cohort separated into low high groups value. Higher CD8 associated no regional lymph node metastasis (p = 0.033). Patients more abundant stroma CD57+ showed (p = 0.005), early clinical stage (p = 0.016). univariate regression analyses that involvement (p < 0.001), (TNM staging I/II vs III/IV, p = 0.007), higher (p < 0.001) all positively correlated longer overall survival. Multivariate analysis (p = 0.008), (p = 0.03) could be independent indicators better None T-bet or ether analysis. AUC accuracy superior compared TNM staging. (AUC = 0.868; 95% CI, 0.785–0.950) (AUC = 0.784; 0.680–0.889) both provided accuracy, which, best predictor. Tumor lymphnode status independently predicts patients. Our results suggest an active microenvironment may targetable drugs.