Astaxanthin reduces isoflurane-induced neuroapoptosis via the PI3K/Akt pathway.
作者： CHUN-MEI WANG , XIAO-LAN CAI , QING-PING WEN
关键词:
摘要: Astaxanthin is an oxygen-containing derivative of carotenoids that effectively suppresses reactive oxygen and has nutritional medicinal value. The mechanisms underlying the effects astaxanthin on isoflurane‑induced neuroapoptosis remain to be fully understood. present study was conducted evaluate protective effect reduce investigate mechanisms. results demonstrated isoflurane induced brain damage, increased caspase‑3 activity suppressed phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (Akt) signaling pathway in in vivo model. However, treatment with significantly inhibited upregulated PI3K/Akt rats. Furthermore, cell growth, apoptosis, enhanced downregulated organotypic hippocampal slice culture. Administration promoted reduced apoptosis activity, neuroapoptosis. downregulation protect against in vitro current suggested reduces isoflurane-induced via activation pathway.
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