Estrogen Stimulation Differentially Impacts Human Male and Female Antigen-Specific T Cell Anti-Tumor Function and Polyfunctionality:

摘要: Abstract Sex-specific differences exist in innate and adaptive immune responses are mediated by hormone signaling. Estrogen is able to differentially modulate the development differentiation of cells, including T cells. However, effect estrogen on cell function, especially at concentrations other than physiological, remains controversial incompletely understood. Immunotherapy one most promising cancer treatments date with a high probability future enhancements. The adoptive transfer genetically modified cells can mediate tumor regression but there still many hurdles enhancing proficiency this treatment. This study demonstrates for first time that major aspect consider designing potent immunotherapies impact patient's sex. Herein, using two different Ag-specific groups, we investigated sex antitumor effector responses, helper cytokine secretion, and, importantly, ...