Reduction in regional cerebral blood flow during normal aging in man.

作者: E Melamed , S Lavy , S Bentin , G Cooper , Y Rinot

DOI: 10.1161/01.STR.11.1.31

关键词:

摘要: Regional cerebral blood flow (rCBF) was measured by the 133Xenon inhalation method in a selected group of 44 normal non-hospitalized, normotensive subjects aged 19 to 79 years. rCBF computed as initial slope index value (ISI). Advancing age associated with significant reductions mean brain and hemispheric ISI well individual levels from all areas both hemispheres. Our findings suggest that decline is not limited elderly but it progressive phenomenon which begins at an earlier age.

参考文章(10)
P. SCHEINBERG, EFFECTS OF AGING ON CEREBRAL CIRCULATION AND METABOLISM Archives of Neurology And Psychiatry. ,vol. 70, pp. 77- 85 ,(1953) , 10.1001/ARCHNEURPSYC.1953.02320310083007
Joseph F. Fazekas, Jack Kleh, Frank A. Finnerty, Influence of age and vascular disease on cerebral hemodynamics and metabolism The American Journal of Medicine. ,vol. 18, pp. 477- 485 ,(1955) , 10.1016/0002-9343(55)90228-X
Seymour S. Kety, Human cerebral blood flow and oxygen consumption as related to aging. Journal of Chronic Diseases. ,vol. 3, pp. 478- 486 ,(1956) , 10.1016/0021-9681(56)90146-1
N. A. Lassen, I. Feinberg, M. H. Lane, BILATERAL STUDIES OF CEREBRAL OXYGEN UPTAKE IN YOUNG AND AGED NORMAL SUBJECTS AND IN PATIENTS WITH ORGANIC DEMENTIA Journal of Clinical Investigation. ,vol. 39, pp. 491- 500 ,(1960) , 10.1172/JCI104063
Henry A. Shenkin, Paul Novak, Bernard Goluboff, Alvin M. Soffe, Leonard Bortin, Doris Golden, Peter Batson, THE EFFECTS OF AGING, ARTERIOSCLEROSIS, AND HYPERTENSION UPON THE CEREBRAL CIRCULATION 1 Journal of Clinical Investigation. ,vol. 32, pp. 459- 465 ,(1953) , 10.1172/JCI102760
D J Wyper, G A Lennox, J O Rowan, Two minute slope inhalation technique for cerebral blood flow measurement in man. 1. Method. Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 39, pp. 141- 146 ,(1976) , 10.1136/JNNP.39.2.141
M. Roth, B.E. Tomlinson, G. Blessed, Observations on the brains of non-demented old people Journal of the Neurological Sciences. ,vol. 7, pp. 331- 356 ,(1968) , 10.1016/0022-510X(68)90154-8
M A Roberts, F I Caird, Computerised tomography and intellectual impairment in the elderly. Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 39, pp. 986- 989 ,(1976) , 10.1136/JNNP.39.10.986
S. A. BARRON, L. JACOBS, W. R. KINKEL, Changes in size of normal lateral ventricles during aging determined by computerized tomography. Neurology. ,vol. 26, pp. 1011- 1011 ,(1976) , 10.1212/WNL.26.11.1011
Niels A. Lassen, Cerebral Blood Flow and Oxygen Consumption in Man Physiological Reviews. ,vol. 39, pp. 183- 238 ,(1959) , 10.1152/PHYSREV.1959.39.2.183