Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses

摘要: Selective autophagy is a catabolic process with which cellular material specifically targeted for degradation by lysosomes. The function of selective autophagic self-components in the regulation innate immunity still unclear. Here we show that Drosophila Kenny, homolog mammalian IKKγ, receptor mediates IκB kinase complex. complex prevents constitutive activation immune deficiency pathway response to commensal microbiota. We autophagy-deficient flies have systemic promotes hyperplasia phenotype midgut. Remarkably, human IKKγ does not interact Atg8-family proteins. Using mathematical model, suggest mechanisms pathogen selection might driven loss LIR motif functionality during evolution. Our results there may been an autophagy-related switch evolution proteins metazoans.