Simulation of elastic wave scattering in cells and tissues at the microscopic level.
作者： Timothy E. Doyle , Adam T. Tew , Keith H. Warnick , Brent L. Carruth
DOI: 10.1121/1.3075569
关键词:
摘要: The scattering of longitudinal and shear waves from spherical, nucleated cells three-dimensional tissues with simple hierarchical microstructures was numerically modeled at the microscopic level using an iterative multipole approach. were a concentric core-shell (nucleus-cytoplasm) structure embedded in extracellular matrix. Using vector expansions boundary conditions, solutions derived for single either solid or fluid properties each cell components. Tissues as structured packings cells. Multiple between simulated addition theorems to translate fields process. Backscattering simulations indicated that changes nuclear diameter had greatest effect on frequency spectra. Simulated wave field images high-frequency spectra (15-75 MHz) containing 1211-2137 exhibited up 20% enhancement amplitudes plasma membrane, significant spectral features due neoplastic other microstructural alterations, detection threshold approximately 8.5% infiltration tumor into normal tissue. These findings suggest histology-based may provide insight fundamental ultrasound-tissue interactions help development new medical technologies.
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