Receptors, Neuropathways, and Mechanisms

摘要: Summary In this article, we have reviewed the different stages of acquisition and processing nociceptive information from peripheral receptor to brain underline plastic changes that accompany tissue injury. For instance, subclassification receptors in nociceptors non-nociceptors (e.g., mechanoreceptors, thermoreceptors) must be understood light sensitization. This phenomenon is probable explanation for primary hyperalgesia, decrease pain threshold at site The observation substance P enhances NMDA-elicited responses suggests these two systems may operate concert prolong amplify afferent input generated by Such barrage induces a state central phenomenon, subliminal zone receptive fields many dorsal horn neurons becomes suprathreshold. These sensitizations probably induce permanent circuits associated with some chronic states. fact, it tempting extrapolate Bach et al5 preventive treatment acute will prevent development syndromes surgical patients.