Delayed cerebrospinal fluid sterilization and adverse outcome of bacterial meningitis in infants and children.

摘要: To determine the clinical importance of CSF cultures that are persistently positive for pathogens in patients treated meningitis with new cephalosporins, records 301 infants and children bacterial enrolled prospectively four efficacy trials cefuroxime or ceftriaxone therapy were reviewed. culture results 20 they sterile at 18 to 36 hours after start 281 patients. Seizures, subdural effusions, hemiparesis found significantly more often during hospitalization those delayed sterilization CSF. Children had a higher incidence neurologic abnormalities time hospital discharge (45% v 19%) follow-up (41% 13%) moderate profound hearing impairment (35% 15%) than did prompt Repeat examination is useful prognostic indicator young meningitis.