Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea.

摘要: SummaryBackground Antibiotic-associated diarrhoea is a common complication of antibiotic use, but it can be prevented with administration probiotics. Aim To update our 2005 meta-analysis on the effectiveness Saccharomyces boulardii in preventing antibiotic-associated children and adults. Methods The Cochrane Library, MEDLINE, EMBASE databases were searched up until May 2015, no language restrictions, for randomised controlled trials; additional references obtained from reviewed articles. The quality evidence was assessed using Grading Recommendations Assessment, Development Evaluation (GRADE) guidelines. Results Twenty-one trials (4780 participants), among which 16 new trials, met inclusion criteria this updated systematic review. Administration S. boulardii compared placebo or treatment reduced risk (as defined by study investigators) patients treated antibiotics 18.7% to 8.5% (risk ratio, RR: 0.47; 95% CI: 0.38–0.57, number needed treat, NNT: 10; 9–13). In children, S. 20.9% 8.8% (6 n=1653, 0.43, 0.3–0.6); adults, 17.4% 8.2% (15 n=3114, 0.49, 0.38–0.63). Moreover, Clostridium difficile-associated diarrhoea; however, reduction significant only (2 n = 579, 0.25; 0.08–0.73) not adults (9 n = 1441, 0.8, 0.47–1.34). Conclusions This confirms that effective reducing adults.