The immediate future for the medical treatment of atrial fibrillation

摘要: Atrial fibrillation is the most commonly sustained cardiac arrhythmia and a common reason for mortality morbidity. causes disease three reasons: i) ventricular rate often high, which leads to symptoms ranging from discomfort life threatening heart failure; ii) rhythm loss of atrioventricular synchrony, reduces diastolic filling may lead iii) atrial contraction lost leading stagnant blood that again thrombi peripheral embolism. Thus, treatment focused on maintenance sinus rhythm, control prevention For all drugs under current development are potassium channel blockers; so-called class III anti-arrhythmic drugs. Those have been further investigated appear be valuable but carry significant risk pro-arrhythmia, in particular Torsade de Pointe tac...