Shaping action sequences in basal ganglia circuits.

摘要: Many behaviors necessary for organism survival are learned anew and become organized as complex sequences of actions. Recent studies suggest that cortico-basal ganglia circuits important chunking isolated movements into precise robust action permit the achievement particular goals. During sequence learning many neurons in basal develop sequence-related activity — related to initiation, execution, termination sequences — suggesting processed units. Corticostriatal plasticity is critical crystallization sequences, development neural activity. Furthermore, this activity differentially expressed direct indirect pathways. These findings have implications understanding symptoms associated with movement psychiatric disorders.