Neuroligin-2 Expression in the Prefrontal Cortex is Involved in Attention Deficits Induced by Peripubertal Stress.
作者： Stamatina Tzanoulinou , Clara García-Mompó , Orbicia Riccio , Jocelyn Grosse , Olivia Zanoletti
DOI: 10.1038/NPP.2015.200
关键词:
摘要: Emerging evidence indicates that attention deficits, which are frequently observed as core symptoms of neuropsychiatric disorders, may be elicited by early life stress. However, the mechanisms mediating these stress effects remain unknown. The prefrontal cortex (PFC) has been implicated in regulation attention, including dysfunctions GABAergic transmission, and it is highly sensitive to Here, we investigated involvement neuroligin-2 (NLGN-2), a synaptic cell adhesion molecule involved stabilization maturation synapses, PFC link between deficits. First, established exposure rats during peripubertal period impairs five-choice serial reaction time task results reductions GABA-synthesizing enzyme glutamic acid decarboxylase different subregions (ie, prelimbic (PL), infralimbic, medial ventral orbitofrontal (OFC) cortex) NLGN-2 PL cortex. In peripubertally stressed animals, expression OFC correlated with measurements. Subsequently, found adeno-associated virus-induced rescue reverses stress-induced deficits regarding omitted trials. Therefore, our findings highlight peripuberty vulnerable stress, leading development dysfunction system expression. Furthermore, underscored promising target treat cognitive alterations, particular attentional manifested augmented omissions continuous performance task.
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