Early invasive versus selectively invasive strategy in patients with non‐ST‐segment elevation acute coronary syndrome: Impact of age

摘要: Background It is unclear whether the benefits of an early invasive strategy (EIS) in patients with non-ST-segment elevation acute coronary syndromes (NSTEACS) equally apply to younger and older individuals. Elderly are generally less likely undergo EIS when compared patients. Objectives We conducted a meta-analysis compare benefit versus selectively (SIS) NSTEACS. We tested hypothesis that magnitude over SIS mainly applies individuals. Methods We extracted data from randomized controlled trials (RCTs) identified through search methodology filters. The primary outcome analysis was composite all-cause death myocardial infarction (MI). Secondary outcomes were MI taken alone re-hospitalization. Results Nine (n = 9,400 patients) eligible. incidence end-point 16.0% 18.3% (OR: 0.85, 95% CI: 0.76–0.95). 8.4% 10.9% 0.75, 0.66–0.87). Similar results obtained for rehospitalization 0.71, 0.55–0.90). did not differ between two groups. reduced re-hospitalization greater extent elderly than (P interaction = 0.044 <0.0001, respectively). These findings confirmed meta-regression analyses. Conclusions In NSTEACS, routine reduces risk end point recurrent © 2013 Wiley Periodicals, Inc.