Signaling by the TNF Receptor Superfamily and T Cell Homeostasis

摘要: TNFR-like receptors are critical mediators of both healthy and pathogenic immune responses. Recent therapeutic approaches aiming at disruption TNF-TNFR interactions have proven to be effective in the treatment rheumatoid arthritis. However, current treatments with anti-TNF antibody or soluble TNFR proteins do not discriminate between TNFR-1 TNFR-2. The identification PLAD its role mediating pre-ligand complex formation receptor function may exploited as a novel target diseases that involves TNF- ligand-receptor pairs. For example, it is possible PLAD-mimicking peptide could specifically block function. Future experiments shall help address questions how these preformed complexes signal, their achieving homeostasis, whether they feasible targets for intervention specific diseases.*To whom correspondence should addressed (e-mail: mlenardo@nih.gov).