Immunohistochemical Profile of 20 Feline Renal Cell Carcinomas

摘要: Renal cell carcinoma (RCC) is uncommon in cats, but makes up the majority of epithelial neoplasms kidney. The immunohistochemical profile 20 feline RCCs (13 tubular carcinomas, four tubulopapillary one papillary and two anaplastic carcinomas) was evaluated. Primary antibodies used were specific for Pax8, KIT, CD10, cytokeratins vimentin. A polymer-based immunoperoxidase procedure used. Nineteen tumours (95%) expressed Pax8; 12 (60%), KIT; 15 (75%), CD10; (100%), cytokeratins; 19 (95%), Nuclear Pax8 immunoreactivity readily apparent, variation labelling intensity present within a given section. KIT reactivity diffuse, cytoplasmic relatively homogeneous. CD10 predominantly membranous along apical border cells less commonly cytoplasmic. intense areas with differentiation absent solid areas. Cytoplasmic cytokeratin expression strong 18 weak two; portion tumour had distinct submembranous expression. Vimentin immunoreactivity, which ranged from diffuse to focal, difficult evaluate due stromal its patchy phenotypically similar neoplastic cells. Fewer non-renal positive than CD10. Considering overall sensitivity specificity, appears be valuable marker distinguishing arising kidney other neoplasms.