Time to loco-regional recurrence after resection of Dukes' B and C colorectal cancer with or without adjuvant postoperative radiotherapy. A multivariate regression analysis.

摘要: Factors influencing time to loco-regional recurrence were identified in a multivariate regression analysis of data from series 468 radically operated patients (260 Dukes' B and 208 C) with carcinoma the rectum rectosigmoid. A number clinical pathological characteristics prospectively collected recorded. In addition, carcinoembryonic antigen (CEA) was measured within 1 week before surgery. The endpoint used below level umbilicus. All followed for at least 5 years or until death. two stages C analysed separate analyses using Cox proportional hazards model. tumours, an increased risk associated perineural invasion, tumour located less than 10 cm anal verge, patient aged above 70 years, small size. necessity resect neighbour organs, venous large size all poor outcome. Postoperative radiotherapy not significant prognosticator control. An update 5-year results randomised study post-operative (50 Gy 2 per fraction overall treatment 7 weeks) showed no survival benefit adjuvant either category statistically improvement control rate. However, when comparison restricted group high-risk there respect (P = 0.03) but 0.23). potential advantage, terms required patients, restricting trials intensified therapies is illustrated.