Probing the Phylogenomics and Putative Pathogenicity Genes of Pythium insidiosum by Oomycete Genome Analyses.

摘要: Pythium insidiosum is a human-pathogenic oomycete. Many patients infected with it lose organs or die. Toward the goal of developing improved treatment options, we want to understand how Py. has evolved become successful human pathogen. Our approach here involved use comparative genomic and other analyses identify genes possible functions in pathogenicity insidiosum. We generated an Oomycete Gene Table used explore genome contents phylogenomic relationships 19 oomycetes. Initial sequence showed that closely related species are not pathogenic humans. also indicated organism harbours secreted adhesin-like proteins, which absent from species. Putative virulence proteins were identified by comparison set known genes. Among them urease Ure1, humans thus potential diagnostic therapeutic target. mass spectrometric data successfully validate expression 30% 14,962 predicted 15 body temperature (37 °C)-dependent This work begins unravel determinants