Experimental reproduction of neonatal diarrhea in young gnotobiotic hares simultaneously associated with Clostridium difficile and other Clostridium strains.

摘要: Clostridium difficile, C. perfringens, and tertium are very often present simultaneously in the feces of conventional diarrheic young hares, whereas these three bacterial species rarely encountered never healthy hares. When a strain each was monoassociated with axenic appearance pathological disorders only observed animals when number difficile exceeded 10(8) per g fresh feces. perfringens or tertium, both, associated diarrhea death occurred more rapidly than hares difficile. became established disassociated The association did not bring about any disorders. It may be concluded that is causal agent neonatal gnotobiotic other strains enhance its pathogenic effect. C alone does play role rats, mice, rabbits.