Clindamycin as an anti-staphylococcal agent--indications and limitations.

摘要: Abstract In a general survey it is stated that for single Staphylococcus aureus infections, clindamycin not considered to be first-line drug. Its chief indication penicillin allergy. Penetration and accumulation of within leukocytes demonstrated in vitro may value the treatment S. diseases resulting large abscesses. An insidious risk development Clostridium difficile diarrhoea limits use ambulatory long-term diabetic osteitis chronic osteomyelitis. Such patients must therefore carefully checked during therapy. staphylococcal endocarditis treated with clindamycin, relapses resistance have been reported. Mixed anaerobic infections skin, subcutaneous tissue, foot, bone joints are primary indications clindamycin. epidermidis especially septicemia endocarditis, suitable therapy due high rate resistance.