Connexins and Pannexins in Bone and Skeletal Muscle

摘要: To discuss current knowledge on the role of connexins and pannexins in musculoskeletal system. Connexins are crucial for development maintenance both bone skeletal muscle. In bone, presence connexin more recently pannexin channels osteoblasts, osteoclasts, osteocytes has been described shown to be essential normal adaptation. muscles, play important roles during regeneration through coordinated regulation metabolic functions via cell-to-cell communication. Further, under pathological conditions, altered expression these proteins can promote muscle atrophy degeneration by stimulating inflammasome activity. this review, we highlight development, maintenance, tissues, with emphasis mechanisms which molecules mediate chemical (e.g., ATP prostaglandin E2) physical mechanical stimulation) stimuli that target system their involvement pathophysiological changes genetic acquired diseases.