Ultraviolet carcinogenesis: environmental effects of ozone depletion.

摘要: Ultraviolet (UV) radiation is a useful agent in the study of skin carcinogenesis. The administered experiments may be selected for spectral composition and measured accurately (Forbes et al. 1982). doses UV given to experimental animals same range as those received by people daily life. tumors induced appear on are accessible observation from an early stage. In hairless mice, caused predominantly squamous cell carcinomas, which also found human after prolonged sun exposure. Experimental studies make it possible investigate influence wavelength, dose (de Gruijl 1983), rate, etc. wavelength-dependence, or “action spectrum,” becoming known better approximation step step. It extends throughout entire wavelength range, with wavelengths differing effectiveness up 4 orders magnitude van der Leun 1992). dose-effect relationship mice basically type epidemiology.