Dialysis removes apolipoprotein C-I, improving very low-density lipoprotein clearance.
作者： G.A. Kaysen
关键词:
摘要: Chronic kidney disease (CKD) is associated with dyslipidemia, characterized by increased levels of triglyceride-rich lipoproteins (TRLPs), including very low-density lipoprotein (VLDL) and intermediate-density (IDL), no change or a reduction in (LDL) low high-density (HDL) levels. Serum triglycerides IDL are risk factors for vascular dialysis patients, whereas LDL not. The principal cause the increase TRLPs decreased removal, not synthesis. clearance defect arises from specific receptors, decreases activity lipases, low-molecular weight apolipoproteins that inhibit interaction between both receptors lipases catabolize them. VLDL patients structurally abnormal metabolized at normal rate lipase (LPL).
core.ac.uk
kidney-international.org
elsevier.com
nature.com
sci-hub.se 参考文章(22)
Laure Dumont, Thomas Gautier, Jean-Paul Pais de Barros, Hélène Laplanche, Denis Blache, Patrick Ducoroy, Jamila Fruchart, Jean-Charles Fruchart, Philippe Gambert, David Masson, Laurent Lagrost, Molecular mechanism of the blockade of plasma cholesteryl ester transfer protein by its physiological inhibitor apolipoprotein CI. Journal of Biological Chemistry. ,vol. 280, pp. 38108- 38116 ,(2005) , 10.1074/JBC.M504678200
Jimmy F. P. Berbée, Caroline C. van der Hoogt, Deepa Sundararaman, Louis M. Havekes, Patrick C. N. Rensen, Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL Journal of Lipid Research. ,vol. 46, pp. 297- 306 ,(2005) , 10.1194/JLR.M400301-JLR200
Kunitoshi Iseki, Masanobu Yamazato, Masahiko Tozawa, Shuichi Takishita, Hypocholesterolemia is a significant predictor of death in a cohort of chronic hemodialysis patients. Kidney International. ,vol. 61, pp. 1887- 1893 ,(2002) , 10.1046/J.1523-1755.2002.00324.X
Tomasz Stompór, Mieczysław Pasowicz, Władysław Sułowicz, Aldona Dembińska-Kieć, Katarzyna Janda, Katarzyna Wójcik, Wiesława Tracz, Anna Zdzienicka, Piotr Klimeczek, Eve Janusz-Grzybowska, An association between coronary artery calcification score, lipid profile, and selected markers of chronic inflammation in ESRD patients treated with peritoneal dialysis American Journal of Kidney Diseases. ,vol. 41, pp. 203- 211 ,(2003) , 10.1053/AJKD.2003.50005
George A. Kaysen, Disorders in high-density metabolism with insulin resistance and chronic kidney disease. Journal of Renal Nutrition. ,vol. 17, pp. 4- 8 ,(2007) , 10.1053/J.JRN.2006.10.002
Choong Kim, Nosratola D. Vaziri, Down-regulation of hepatic LDL receptor-related protein (LRP) in chronic renal failure Kidney International. ,vol. 67, pp. 1028- 1032 ,(2005) , 10.1111/J.1523-1755.2005.00166.X
Caroline C. van der Hoogt, Jimmy F.P. Berbée, Sonia M.S. Espirito Santo, Gery Gerritsen, Yvonne D. Krom, André van der Zee, Louis M. Havekes, Ko Willems van Dijk, Patrick C.N. Rensen, Apolipoprotein CI causes hypertriglyceridemia independent of the very-low-density lipoprotein receptor and apolipoprotein CIII in mice Biochimica et Biophysica Acta. ,vol. 1761, pp. 213- 220 ,(2006) , 10.1016/J.BBALIP.2006.01.002
Man Kam Chan, Jahmwant Persaud, Zachariah Varghese, John F. Moorhead, Pathogenic roles of post-heparin lipases in lipid abnormalities in hemodialysis patients Kidney International. ,vol. 25, pp. 812- 818 ,(1984) , 10.1038/KI.1984.94
Diana M. Lee, Carolyn Knight-Gibson, Ola Samuelsson, Per-Ola Attman, Chi-Sun Wang, Petar Alaupovic, Lipoprotein particle abnormalities and the impaired lipolysis in renal insufficiency. Kidney International. ,vol. 61, pp. 209- 218 ,(2002) , 10.1046/J.1523-1755.2002.00116.X
R. L. Walzem, S. Watkins, E. N. Frankel, R. J. Hansen, J. B. German, Older plasma lipoproteins are more susceptible to oxidation: a linking mechanism for the lipid and oxidation theories of atherosclerotic cardiovascular disease Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 7460- 7464 ,(1995) , 10.1073/PNAS.92.16.7460