Trait-related decision-making impairment in the three phases of bipolar disorder

摘要: Background In bipolar disorder (BD), little is known about how deficits in neurocognitive functions such as decision-making are related to phase of illness. We predicted that manic, depressed, and euthymic patients (BPs) would display impaired decision-making, we tested whether clinical characteristics could predict patients' performance. Methods Subjects ( N = 317; age range: 18–65 years) including 167 BPs (45 manic 32 depressed inpatients, 90 outpatients) 150 age-, IQ-, gender-matched healthy control (HC) participants, were included within three university psychiatric hospitals using a cross-sectional design. The relationship between predictor variables was assessed by one-step multivariate analysis. main outcome measures overall ability on the Iowa Gambling Task (IGT) an index sensitivity punishment frequency. Results Manic, selected significantly more cards from risky decks than HCs p Conclusions have trait-related impairment does not vary across illness phase. However, some subtle differences BD groups individual deck analyses may point state influences reinforcement mechanisms, addition fundamental trait risk-sensitive decision making.