摘要: Resume La maladie cœliaque (MC) est une inflammatoire intestinale secondaire a l’ingestion de gluten survenant chez des patients genetiquement predisposes (HLA DQ2/DQ8). Sa prevalence estimee environ 1/100 en Europe et aux Etats-Unis. Il s’agit d’une extremement proteiforme dont les seules manifestations peuvent etre anemie ferriprive, aphtose buccale recidivante, amenorrhee ou osteoarticulaires. Le diagnostic repose sur la mise en evidence histologique atrophie villositaire du grele proximal presence d’anticorps seriques specifiques. traitement l’eviction vie alimentaire (ble, seigle, orge). permet prevenir complications neoplasiques telles que adenocarcinomes lymphomes l’osteopenie. principale cause l’echec regime sa mauvaise observance. Dans le cas contraire, graves MC, sprue refractaire clonale lymphome T intestinal, doivent recherchees. Les principaux enjeux actuels sont trouver alternatives au sans (RSG) ainsi nouvelles therapeutiques efficaces dans lymphomateuses.
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