Lipid metabolism in Trypanosoma cruzi: A review.

摘要: The cellular membranes of Trypanosoma cruzi, like all eukaryotes, contain varying amounts phospholipids, sphingolipids, neutral lipids and sterols. A multitude pathways exist for the de novo synthesis these lipid families but cruzi has also become adapted to scavenge some from host. Completion TriTryp genomes led identification many putative genes involved in synthesis, revealing interesting differences higher eukaryotes. Although enzymes have yet be characterised, completed experiments shown indispensability metabolic pathways. Furthermore, bioactive their effects on host are becoming increasingly studied. Further studies metabolism will no doubt reveal attractive targets therapeutic intervention as well interplay between parasite lipids, response pathogenesis.