The contribution of pneumolysin to the pathogenicity of Streptococcus pneumoniae.
作者： James C. Paton
DOI: 10.1016/0966-842X(96)81526-5
关键词:
摘要: The antiphagocytic polysaccharide capsule of Streptococcus pneumoniae has long been considered the principal virulence determinant this organism. However, there is growing evidence that toxin pneumolysin plays an important role in pathogenesis pneumococcal disease and may thus be a significant additional target for vaccine development.
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sci-hub.se 参考文章(30)
S Bhakdi, J Tranum-Jensen, Complement activation and attack on autologous cell membranes induced by streptolysin-O. Infection and Immunity. ,vol. 48, pp. 713- 719 ,(1985) , 10.1128/IAI.48.3.713-719.1985
A M Berry, J Yother, D E Briles, D Hansman, J C Paton, Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae. Infection and Immunity. ,vol. 57, pp. 2037- 2042 ,(1989) , 10.1128/IAI.57.7.2037-2042.1989
F K Saunders, T J Mitchell, J A Walker, P W Andrew, G J Boulnois, Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity. Infection and Immunity. ,vol. 57, pp. 2547- 2552 ,(1989) , 10.1128/IAI.57.8.2547-2552.1989
K A Benton, M P Everson, D E Briles, A pneumolysin-negative mutant of Streptococcus pneumoniae causes chronic bacteremia rather than acute sepsis in mice. Infection and Immunity. ,vol. 63, pp. 448- 455 ,(1995) , 10.1128/IAI.63.2.448-455.1995
Chi-Jen Lee, Robert A. Lock, Peter W. Andrew, Timothy J. Mitchell, David Hansman, James C. Paton, Protection of infant mice from challenge with Strptococcus pneumoniae type 19F by immunization with a type 19F polysaccharide—pneumolysoid conjugate web science. ,vol. 12, pp. 875- 878 ,(1994) , 10.1016/0264-410X(94)90028-0
Farzin Robert Amaee, Spiro D. Comis, Michael P. Osborne, NG-methyl-L-arginine protects the guinea pig cochlea from the cytotoxic effects of pneumolysin Acta Oto-laryngologica. ,vol. 115, pp. 386- 391 ,(1995) , 10.3109/00016489509139334
C. Feldman, N. C. Munro, P. K. Jeffery, T. J. Mitchell, P. W. Andrew, G. J. Boulnois, D. Guerreiro, J. A. L. Rohde, H. C. Todd, P. J. Cole, R. Wilson, Pneumolysin Induces the Salient Histologic Features of Pneumococcal Infection in the Rat Lung In Vivo American Journal of Respiratory Cell and Molecular Biology. ,vol. 5, pp. 416- 423 ,(1991) , 10.1165/AJRCMB/5.5.416
M. K. Johnson, M. C. Callegan, L. S. Engel, R. J. O'callaghan, J. M. Hill, J. A. Hobden, G. J. Boulnois, P. W. Andrew, T. J. Mitchell, Growth and virulence of a complement-activation-negative mutant of Streptococcus pneumoniae in the rabbit cornea web science. ,vol. 14, pp. 281- 284 ,(1995) , 10.3109/02713689509033527
J B Rubins, D Charboneau, J C Paton, T J Mitchell, P W Andrew, E N Janoff, Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia. Journal of Clinical Investigation. ,vol. 95, pp. 142- 150 ,(1995) , 10.1172/JCI117631
Richard H.G. Owen, Graham J. Boulnois, Peter W. Andrew, Timothy J. Mitchell, A role in cell-binding for the C-terminus of pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae. Fems Microbiology Letters. ,vol. 121, pp. 217- 221 ,(1994) , 10.1111/J.1574-6968.1994.TB07101.X