Milk Protein Quantity and Quality in Low-Birthweight Infants: I. Metabolic Responses and Effects on Growth

摘要: The optimal quantity and quality of protein for low-birthweight infants is undefined. In this study, 106 well, appropriate-for-gestational age, weighing 2,100 gm or less were grouped in three gestational age categories: T1 = 28 to 30 weeks; T2 31 33 T3 34 36 weeks. Each group was assigned randomly either banked human milk (BM) one four isocaloric formulas varying but not mineral content fat content: formula 1 1.5 per 100 ml, 60 parts bovine whey proteins 40 caseins: 2 3.0 60:40; 3 18:82; 4 18:82. Caloric intake 117 kcal/150 ml/kg/day the formulas. Human fed at 170 order attain a caloric approximately equal that No significant differences found rate growth crown-rump length, femoral head circumference, gain weight from time regaining birthweight discharge 2,400 gm. Blood urea nitrogen, urine osmolarity, total serum protein, albumin, aiud globulin varied directly with diet: F2, F4 > F1, F3 BM. ammonia concentration both qualtiy F3, Metabolic acidosis more frequent, severe, prolonged casein-predominant (F3, F4) than those protein-predominant (Fl, F2).