Chronic alcohol causes alteration of lipidome profiling in brain

摘要: Abstract Much efforts have been tried to clarify the molecular mechanism of alcohol-induced brain damage from perspective genome and protein; however, effect chronic alcohol exposure on global lipid profiling is unclear. In present study, by using Q-TOF/MS-based lipidomics approach, we investigated comprehensive lipidome rats orally administrated with daily, continuously for one year. Through systematically analysis all lipids in prefrontal cortex (PFC) striatum region, found that long-term profoundly modified profiling. Notably, three kinds classes, glycerophospholipid (GP), glycerolipid (GL) fatty acyls (FA), were significantly increased these two regions. Interestingly, most involved synthetic pathways endoplasmic reticulum (ER), which may result ER stress-related metabolic disruption. Moreover, alcohol-modified species displayed long length carbon chain high degree unsaturation. Taken together, our results firstly markedly modifies lipidomic profiling, activate stress eventually neurotoxicity. These findings provide a new insight into alcohol-related damage.