Endocrinopathies and cancer cachexia.

作者: Rony Dev , Egidio Del Fabbro , Shalini Dalal

DOI: 10.1097/SPC.0000000000000464

关键词:

摘要: Purpose of review Cancer cachexia cannot be easily reversed by standard nutritional support and interventions directed at underlying metabolic derangements may needed to prevent or reverse maintain healthy body composition. The following will highlight the contribution potential therapeutic for insulin resistance, alterations in ghrelin signaling, hypogonadism cancer patients. Recent findings In addition decreased caloric intake, chronic inflammation, altered metabolism glucose, proteins lipids, endocrine abnormalities can propagate weight loss changes composition Summary cachexia, muscle mass with without fat mass, is a multifactorial syndrome, which associated increased morbidity mortality. Currently, limited options treatment patients exist, lead clinically meaningful improvements gain performance status. Treatment low testosterone, sensitivity, future, lean cachexia.

参考文章(61)
Masayasu Kojima, Kenji Kangawa, Structure and function of ghrelin. Results and problems in cell differentiation. ,vol. 46, pp. 89- 115 ,(2008) , 10.1007/400_2007_049
Peeters Tl, Central and peripheral mechanisms by which ghrelin regulates gut motility. Journal of Physiology and Pharmacology. ,vol. 54, pp. 95- 103 ,(2003)
Christopher P. Holroyde, Charles L. Skutches, Guenther Boden, George A. Reichard, Glucose metabolism in cachectic patients with colorectal cancer. Cancer Research. ,vol. 44, pp. 5910- 5913 ,(1984)
Sofia Tsirona, Marinella Tzanela, Efi Botoula, Ion Belenis, D. Rondogianni, Stylianos Tsagarakis, Clinical Presentation and Long-Term Outcome of Patients With Ectopic Acth Syndrome Due to Bronchial Carcinoid Tumors: A One-Center Experience Endocrine Practice. ,vol. 21, pp. 1104- 1110 ,(2015) , 10.4158/EP15647.OR
Kent Lundholm, Ulla Körner, Lena Gunnebo, Petra Sixt-Ammilon, Marita Fouladiun, Peter Daneryd, Ingvar Bosaeus, Insulin treatment in cancer cachexia: effects on survival, metabolism, and physical functioning. Clinical Cancer Research. ,vol. 13, pp. 2699- 2706 ,(2007) , 10.1158/1078-0432.CCR-06-2720
Mark D DeBoer, Animal models of anorexia and cachexia Expert Opinion on Drug Discovery. ,vol. 4, pp. 1145- 1155 ,(2009) , 10.1517/17460440903300842
Marion F. Winkler, Quality of life in adult home parenteral nutrition patients. Journal of Parenteral and Enteral Nutrition. ,vol. 29, pp. 162- 170 ,(2005) , 10.1177/0148607105029003162
William J. Evans, John E. Morley, Josep Argilés, Connie Bales, Vickie Baracos, Denis Guttridge, Aminah Jatoi, Kamyar Kalantar-Zadeh, Herbert Lochs, Giovanni Mantovani, Daniel Marks, William E. Mitch, Maurizio Muscaritoli, Armine Najand, Piotr Ponikowski, Filippo Rossi Fanelli, Morrie Schambelan, Annemie Schols, Michael Schuster, David Thomas, Robert Wolfe, Stefan D. Anker, Cachexia: a new definition. Clinical Nutrition. ,vol. 27, pp. 793- 799 ,(2008) , 10.1016/J.CLNU.2008.06.013
Tohru Yasuda, Takayuki Masaki, Tetsuya Kakuma, Hironobu Yoshimatsu, Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats. Neuroscience Letters. ,vol. 349, pp. 75- 78 ,(2003) , 10.1016/S0304-3940(03)00789-4