Thymus and Myasthenia Gravis. Pathophysiological and Clinical Features

摘要: In 1672 Thomas Willis published a book, “De anima brutorum” in which he wrote about “a woman who temporarily lost her power of speech and became mute as fish” [1]. This has been interpreted being the first written description myasthenia gravis (MG). Others give credit to Wilks for report disease 1877, characterized bulbar palsy without anatomic lesion [2]. The reasonably complete accounts were those Erb 1878 Goldflam 1893 [3, 4] many years thereafter, disorder was referred Erb- syndrome. Jolly use name 1895 demonstrate “myasthenic reaction” muscle repeatedly stimulated by Faradism [5], introducing basic criteria instrumental techniques MG diagnosis, repetitive nerve stimulation, elaborated later Desmedt [6].