Linkage analysis with an alternative formulation for the mixed model of inheritance: The finite polygenic mixed model
作者： C Stricker , R L Fernando , R C Elston
DOI: 10.1093/GENETICS/141.4.1651
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摘要: This paper presents an extension of the finite polygenic mixed model Fernando et al. (1994) to linkage analysis. The model, extended for analysis, leads a likelihood that can be calculated using efficient algorithms developed oligogenic models. For comparison, analysis 5 simulated 4021-member pedigrees was performed usual inheritance, approximated by Hasstedt (1982), and presented here. Maximum estimates could inferred closer values in these pedigrees.
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osti.gov参考文章(23)
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