LINKAGE DISEQUILIBRIUM AND ASSOCIATIVE OVERDOMINANCE DUE TO RANDOM GENETIC DRIFT
作者： TOMOKO OHTA
DOI: 10.1266/JJG.46.195
关键词:
摘要: Random frequency drift causes linkage disequilibrium and associative overdominance, they have important bearing on the investigation of fitness values marker alleles. Very often, experimental results merely reflect effects genetic background rather than effect markers per se. Approximate magnitude overdominance were estimated assuming various situations in natural populations. They mainly depend Nec, product effective population number recombination fraction. Also, was two models In one model, a neutral gene is linked with mildly deleterious mutants, other it overdominant loci. Based results, importance both populations discussed.
sci-hub.se 参考文章(22)
Terumi Mukai, The Genetic Structure of Natural Populations of DROSOPHILA MELANOGASTER. VIII. Natural Selection on the Degree of Dominance of Viability Polygenes Genetics. ,vol. 63, pp. 467- 478 ,(1969) , 10.1093/GENETICS/63.2.467
John A Sved, Francisco J Ayala, A Population Cage Test for Heterosis in DROSOPHILA PSEUDOOBSCURA Genetics. ,vol. 66, pp. 97- 113 ,(1970) , 10.1093/GENETICS/66.1.97
Tomoko Ohta, Motoo Kimura, LINKAGE DISEQUILIBRIUM BETWEEN TWO SEGREGATING NUCLEOTIDE SITES UNDER THE STEADY FLUX OF MUTATIONS IN A FINITE POPULATION Genetics. ,vol. 68, pp. 571- 580 ,(1971) , 10.1093/GENETICS/68.4.571
J. A. Sved, The stability of linked systems of loci with a small population size. Genetics. ,vol. 59, pp. 543- 563 ,(1968) , 10.1093/GENETICS/59.4.543
Samuel Karlin, James McGregor, Rates and probabilities of fixation for two locus random mating finite populations without selection. Genetics. ,vol. 58, pp. 141- 159 ,(1968) , 10.1093/GENETICS/58.1.141
Alan Robertson, Selection for heterozygotes in small populations. Genetics. ,vol. 47, pp. 1291- 1300 ,(1962) , 10.1093/GENETICS/47.9.1291
Tomoko Ohta, Motoo Kimura, Behavior of Neutral Mutants Influenced by Associated Overdominant Loci in Finite Populations Genetics. ,vol. 69, pp. 247- 260 ,(1971) , 10.1093/GENETICS/69.2.247
Motoo Kimura, A MODEL OF A GENETIC SYSTEM WHICH LEADS TO CLOSER LINKAGE BY NATURAL SELECTION Evolution. ,vol. 10, pp. 278- 287 ,(1956) , 10.1111/J.1558-5646.1956.TB02852.X
W. G. Hill, Alan Robertson, Linkage disequilibrium in finite populations Theoretical and Applied Genetics. ,vol. 38, pp. 226- 231 ,(1968) , 10.1007/BF01245622
M. Nei, The frequency distribution of lethal chromosomes in finite populations Proceedings of the National Academy of Sciences of the United States of America. ,vol. 60, pp. 517- 524 ,(1968) , 10.1073/PNAS.60.2.517